198. Haolin Cao, Jing Jiang, Lei Chen, Lizeng Gao. Mimicomes: Mimicking Multienzyme System by Artificial Design. Advanced Healthcare Materials. 2024, https://doi.org/10.1002/adhm.202402372
197. Ruofei Zhang, Bing Jiang, Kelong Fan, Lizeng Gao, Xiyun Yan. Designing nanozymes for in vivo applications. Nature Reviews Bioengineering. 2024. https://doi.org/10.1038/s44222-024-00205-1
196. Ye Yuan, Lei Chen, Kexu Song, Miaomiao Cheng, Ling Fang, Lingfei Kong, Lanlan Yu, Ruonan Wang, Zhendong Fu, Minmin Sun, Qian Wang, Chengjun Cui, Haojun Wang, Jiuyang He, Xiaonan Wang, Yuan Liu, Bing Jiang, Jing Jiang, Chenxuan Wang, Xiyun Yan, Xinzheng Zhang, Lizeng Gao. Stable peptide-assembled nanozyme .mimicking dual antifungal actions. Nature Communications. 2024, 15. https://doi.org/10.1038/s41467-024-50094-6
195. Wu, Y., Tian, J., Sun, M., Gao, L., Xu, J., & Niu, Z.. Embedding an esterase mimic inside polyesters to realize rapid and complete degradation without compromising their utility. Green Chemistry. 2024, 26(5), 2851-2857. https://doi.org/10.1039/d3gc04500e
194. Wang, X., Liu, T., Chen, M., Liang, Q., Jiang, J., Chen, L., Fan, K., Zhang, J., & Gao, L.. An Erythrocyte-Templated Iron Single-Atom Nanozyme for Wound Healing. Advanced Science. 2024, 11(6). https://doi.org/10.1002/advs.202307844
193. Qiu, L., Sun, M., Chen, L., Jiang, J., Fu, Z., Wang, Y., Bi, Y., Guo, Q., Bai, H., Chen, S., Gao, L., & Chang, G.. Iron-Confined CRISPR/Cas9-Ribonucleoprotein Delivery System for Redox-Responsive Gene Editing. Small. 2024, https://doi.org/10.1002/smll.202309431
192. Qin, T., Chen, Y., Miao, X., Shao, M., Xu, N., Mou, C., Chen, Z., Yin, Y., Chen, S., Yin, Y., Gao, L., Peng, D., & Liu, X.. Low-Temperature Adaptive Single-Atom Iron Nanozymes against Viruses in the Cold Chain. Advanced Materials. 2024. https://doi.org/10.1002/adma.202309669
191. Meng, X., Fan, H., Chen, L., He, J., Hong, C., Xie, J., Hou, Y., Wang, K., Gao, X., Gao, L., Yan, X., & Fan, K.. Ultrasmall metal alloy nanozymes mimicking neutrophil enzymatic cascades for tumor catalytic therapy. Nat Commun. 2024, 15(1), 1626-1626. https://doi.org/10.1038/s41467-024-45668-3
190. Ma, L., Zheng, J. J., Zhou, N., Zhang, R., Fang, L., Yang, Y., Gao, X., Chen, C., Yan, X., & Fan, K.. A natural biogenic nanozyme for scavenging superoxide radicals. Nat Commun. 2024, 15(1), 233. https://doi.org/10.1038/s41467-023-44463-w
189. Hong, J., Guo, Z., Duan, D., Zhang, Y., Chen, X., Li, Y., Tu, Z., Feng, L., Chen, L., & Yan, X. (2024). Highly sensitive nanozyme strip: an effective tool for forensic material evidence identification. Nano Research. 2024, 1-7. https://doi.org/10.1007/s12274-023-6012-4
188. Gong, H., Wang, X., Hu, X., Liao, M., Yuan, C., Lu, J. R., Gao, L., & Yan, X.. Effective Treatment of Helicobacter pylori Infection Using Supramolecular Antimicrobial Peptide Hydrogels. Biomacromolecules. 2024，25(3), 1602-1611. https://doi.org/10.1021/acs.biomac.3c01141
187. Gao, L., Wei, H., Dong, S., & Yan, X.. The Nanozymes. Advanced Materials. 2024，36(10)：2305249. https://doi.org/10.1002/adma.202305249
186. Fan, H., Zhang, R., Fan, K., Gao, L., & Yan, X.. Exploring the Specificity of Nanozymes. Acs Nano. 2024，18(4), 2533-2540. https://doi.org/10.1021/acsnano.3c07680
185. Cao, H., Yuan, Y., Zhao, R., Shi, W., Jiang, J., Gao, Y., Chen, L., & Gao, L.. Deciphering the Catalytic Mechanism of Peroxidase-like Activity of Iron Sulfide Nanozymes. Acs Applied Materials & Interfaces. 2024，16(24), 30958-30966. https://doi.org/10.1021/acsami.4c06024
184. Fan, X., Zhang, T., Ding, X., Gu, Y., Li, Q., Jiang, W., & Fan, K.. Bioinspired Metal-organic Framework Nanozyme Reinforced with Thermosensitive Hydrogel for Regulating Inflammatory Responses in Parkinson's Disease. Nano Research. 2024, 17, 858–865. https://doi.org/10.1007/s12274-023-6304-8
183. Zhu, M., Zhuang, J., Li, Z., Liu, Q., Zhao, R., Gao, Z., Midgley, A. C., Qi, T., Tian, J., & Zhang, Z.. Machine-learning-assisted single-vessel analysis of nanoparticle permeability in tumour vasculatures. Nature Nanotechnology. 2023, 1-10. https://doi.org/10.1038/s41565-023-01323-4
182. Zhou, J., Xu, D., Tian, G., He, Q., Zhang, X., Liao, J., Mei, L., Chen, L., Gao, L., & Zhao, L.. Coordination-driven self-assembly strategy-activated Cu single-atom nanozymes for catalytic tumor-specific therapy. Journal of the American Chemical Society. 2023, 145(7), 4279-4293. https://doi.org/10.1021/jacs.2c13597
181. ZHANG, X.-E., WANG, W., YAN, X., & PAN, J.. Strengthen Basic Research and Consolidate Foundation for Self-reliance and Self-improvement in Science and Technology. Bulletin of Chinese Academy of Sciences (Chinese Version). 2023, 38(5), 755-758. https://doi.org/10.16418/j.issn.1000-3045.20230512001
180. Yuan, Y., Chen, L., Kong, L., Qiu, L., Fu, Z., Sun, M., Liu, Y., Cheng, M., Ma, S., Wang, X., Zhao, C., Jiang, J., Zhang, X., Wang, L., & Gao, L.. Histidine modulates amyloid-like assembly of peptide nanomaterials and confers enzyme-like activity. Nature Communications. 2023, 14(1), 5808. https://doi.org/10.1038/s41467-023-41591-1
179. Xu, Z. B., Zhu, Y. F., Xie, M. K., Liu, K. K., Cai, L. L., Wang, H. H., Li, D. D., Chen, H., & Gao, L. Z.. Mackinawite nanozymes as reactive oxygen species scavengers for acute kidney injury alleviation. Journal of Nanobiotechnology. 2023， 21(1). https://doi.org/10.1186/s12951-023-02034-7
178. WU, X., ZHANG, R., YAN, X., & FAN, K.. Nanozyme: a New Approach for Anti-microbial Infections. 无机材料学报. 2023, 38(1). https://doi.org/10.15541/jim20220578
177. Wei, H., Li, G., & Li, J.. Biomedical Nanozymes: From Diagnostics to Therapeutics. Springer Nature. 2023: eBook ISBN: 978-981-99-3338-9
176. Wang, Z., Zhao, Y., Hou, Y., Tang, G., Zhang, R., Yang, Y., Yan, X., & Fan, K.. A Thrombin-Activated Peptide-Templated Nanozyme for Remedying Ischemic Stroke Via Thrombolytic and Neuroprotective Actions. Advanced Materials. 2023: e2210144. https://doi.org/10.1002/adma.202210144
175. Wang, M., Liu, H., & Fan, K.. Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers. Small Methods: 2301049. https://doi.org/10.1002/smtd.202301049
174. Wang, D., Wang, J., Liu, D., He, J., Wang, M., Huang, H., Nie, G., Ding, H., & Yan, X.. Rapid and sensitive detection of Epstein-Barr virus antibodies in nasopharyngeal carcinoma by chemiluminescence strips based on iron-porphyrin single atom nanozyme. Nano Research. 2023, 1-10. https://doi.org/10.1007/s12274-023-5915-4
173. Wang, D., Wang, J., Gao, X. J., Ding, H., Yang, M., He, Z., Xie, J., Zhang, Z., Huang, H., & Nie, G.. Employing Noble Metal‐Porphyrins to Engineer Robust and Highly Active Single‐Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma. Advanced Materials. 2023: 2310033. https://doi.org/10.1002/adma.202310033
172. Shi, Y., Li, H., Chu, D., Lin, W., Wang, X., Wu, Y., Li, K., Wang, H., Li, D., & Xu, Z.. Rescuing Nucleus Pulposus Cells From Senescence via Dual‐Functional Greigite Nanozyme to Alleviate Intervertebral Disc Degeneration. Advanced Science. 2023, 10(25): 2300988. https://doi.org/10.1002/advs.202300988
171. Shen, B., Li, W., Wang, Y., Cheng, S., Wang, X., Zhu, L., Zhang, Y., Gao, L., & Jiang, L.. Rapid capture and killing of bacteria by lyophilized nFeS-Hydrogel for improved healing of infected wounds. Biomaterials advances. 2023, 144: 213207. https://doi.org/10.1016/j.bioadv.2022.213207
170. Miao, X., Yin, Y., Chen, Y., Bi, W., Yin, Y., Chen, S., Peng, D., Gao, L., Qin, T., & Liu, X.. Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus. Advanced Science. 2023, 10(17): e2206869. https://doi.org/10.1002/advs.202206869
169. Lyu, M., Luo, M., Li, J., Akakuru, O. U., Fan, X., Cao, Z., Fan, K., & Jiang, W.. Personalized Carbon Monoxide‐Loaded Biomimetic Single‐Atom Nanozyme for Ferroptosis‐Enhanced FLASH Radioimmunotherapy. Advanced Functional Materials. 2023: 2306930. https://doi.org/10.1002/adfm.202306930
168. Luo, Y., Luo, H., Zou, S., Jiang, J., Duan, D., Chen, L., & Gao, L.. An In Situ Study on Nanozyme Performance to Optimize Nanozyme-Strip for Aβ Detection. Sensors. 2023, 23(7): 3414. https://doi.org/10.3390/s23073414
167. Liu, Y., Yan, X., & Wei, H.. Medical Nanozymes for Therapeutics. Springer Link. 2023, 285-329. https://link.springer.com/referenceworkentry/10.1007/978-981-16-8984-0_26
166. Liu, Y., Wang, X., Fan, X., Ge, M., Fang, L., Yuan, Y., Chen, L., Jiang, J., Cao, A., & Gao, L.. Coordination‐Precipitation Synthesis of Metal Sulfide with Phase Transformation Enhanced Reactivity against Antibiotic‐Resistant Bacteria. Advanced Functional Materials. 2023, 33(13): 2212655. https://doi.org/10.1002/adfm.202212655
165. Liu, R., Liang, Q., Luo, J. Q., Li, Y. X., Zhang, X., Fan, K., & Du, J. Z.. Ferritin‐Based Nanocomposite Hydrogel Promotes Tumor Penetration and Enhances Cancer Chemoimmunotherapy. Advanced Science, 2023: 2305217. https://doi.org/10.1002/advs.202305217
164. Liu, C., Fan, W., Cheng, W. X., Gu, Y., Chen, Y., Zhou, W., Yu, X. F., Chen, M., Zhu, M., & Fan, K.. Red Emissive Carbon Dot Superoxide Dismutase Nanozyme for Bioimaging and Ameliorating Acute Lung Injury. Advanced Functional Materials. 2023, 33(19): 2370116. https://doi.org/10.1002/adfm.202213856
163. Li, Z., Gong, R., Abbas, G., Feng, X., Wang, X., Wang, J., Huang, H., Han, J., Zhang, B., & Nie, G.. Dual Phase‐Conversion Strategy Reinforced Otitis Media Therapy Using Metastable Iron Sulfide‐Loaded Thermosensitive Hydrogel. Advanced Therapeutics. 2023, 6(8): 2300073. https://doi.org/10.1002/adtp.202300073
162. Li, Y., Zhang, Y., Dong, Y., Akakuru, O. U., Yao, X., Yi, J., Li, X., Wang, L., Lou, X., & Zhu, B.. Ablation of Gap Junction Protein Improves the Efficiency of Nanozyme‐Mediated Catalytic/Starvation/Mild‐Temperature Photothermal Therapy. Advanced Materials. 2023, 35(22): 2210464. ttps://doi.org/10.1002/adma.202210464
161. Li, Y., Zhang, R., Yan, X., & Fan, K.. Machine learning facilitating the rational design of nanozymes. Journal of Materials Chemistry B. 2023, 11, 6466-6477. https://doi.org/10.1039/D3TB00842H
160. Li, Y., Dong, Y., Zhou, X., & Fan, K.. Nanotechnology connecting copper metabolism and tumor therapy. MedComm–Biomaterials and Applications. 2023, 2(2): e36. https://doi.org/10.1002/mba2.36
159. Li, Q.-Z., Fan, H., Wang, Z., Zheng, J.-J., Fan, K., Yan, X., & Gao, X.. Mechanism and Kinetics-Guided Discovery of Nanometal Scissors to Cut Phosphoester Bonds. ACS Catalysis. 2023, 13(1), 504-514. https://doi.org/10.1021/acscatal.2c05094
158. Li, Q., Wu, T., Akakuru, O. U., Song, N., Liu, W., Jiang, W., & Fan, K.. A Dual Synergetic Nanoreactor for Managing Parkinson's Disease by Regulating Inflammation and Mitigating Oxidative Damage. Advanced Functional Materials. 2023: 2214826. https://doi.org/10.1002/adfm.202214826
157. Li, K., Hu, S. H., Huang, J. H., Shi, Y., Lin, W. Z., Liu, X. Y., Mao, W. W., Wu, C. B., Pan, C., Xu, Z. B., Wang, H. H., Gao, L. Z., & Chen, H.. Targeting ROS-induced osteoblast senescence and RANKL production by Prussian blue nanozyme based gene editing platform to reverse osteoporosis. Nano Today. 2023, 50. https://doi.org/10.1016/j.nantod.2023.101839
156. Li, J., Zhang, Z., Zhang, B., Yan, X., & Fan, K.. Transferrin receptor 1 targeted nanomedicine for brain tumor therapy. Biomaterials Science. 2023, 11, 3394-3413. https://doi.org/10.1039/d2bm02152h
155. Li, J., Cai, X., Jiang, P., Wang, H., Zhang, S., Sun, T., Chen, C., & Fan, K.. Co‐based Nanozymatic Profiling: Advances Spanning Chemistry, Biomedical, and Environmental Sciences. Advanced Materials. 2023: 2307337. https://doi.org/10.1002/adma.202307337
154. Li, B., Ma, R., Chen, L., Zhou, C., Zhang, Y.-X., Wang, X., Huang, H., Hu, Q., Zheng, X., & Yang, J.. Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus. Nature Communications. 2023, 14(1), 7312. https://doi.org/10.1038/s41467-023-43176-4
153. Jing, L., An, Y., Cai, T., Xiang, J., Li, B., Guo, J., Ma, X., Wei, L., Tian, Y., Cheng, X., Chen, X., Liu, Z., Feng, J., Yang, F., Yan, X., & Duan, H.. A subpopulation of CD146+ macrophages enhances antitumor immunity by activating the NLRP3 inflammasome. Cellular & Molecular Immunology. 2023, 20, 908-923. https://doi.org/10.1038/s41423-023-01047-4
152. Jiang, W., Li, Q., Zhang, R., Li, J., Lin, Q., Li, J., Zhou, X., Yan, X., & Fan, K.. Chiral metal-organic frameworks incorporating nanozymes as neuroinflammation inhibitors for managing Parkinson’s disease. Nature Communications. 2023, 14, 8137. https://doi.org/10.1038/s41467-023-43870-3
151. Jiang, B., Yan, X., Zhang, S., Jiang, W., Wang, S., Song, K., Ge, M., Zhang, L., Yan, X. Y., & Jiang, B.. Cancer cell membrane fused liposomal platinum (IV) prodrugs overcome cisplatin resistance in esophageal squamous cell carcinoma chemotherapy. Journal of Materials Chemistry B. 2023, 11, 11384-11393. https://doi.org/10.1039/d3tb01997g
150. Hajizade, A., Ahmadian, G., Fan, K., Zhu, M., & Arpanaei, A.. Nanotechnology-based detection, prevention and treatment of infectious diseases. Frontiers in Microbiology. 2023, 14: 1224727. https://doi.org/10.3389/fmicb.2023.1224727
149. Gao, W., He, J., Chen, L., Meng, X., Ma, Y., Cheng, L., Tu, K., Gao, X., Liu, C., & Zhang, M.. Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme. Nature Communications. 2023, 14(1), 160. https://doi.org/10.1038/s41467-023-35828-2
148. Fang, L., Zhang, R., Shi, L., Xie, J., Ma, L., Yang, Y., Yan, X., & Fan, K.. Protein‐Nanocaged Selenium Induces t (8; 21) Leukemia Cell Differentiation via Epigenetic Regulation. Advanced Science. 2023: 2300698. https://doi.org/10.1002/advs.202300698
147. Fan, K., Gao, L., Wei, H., Jiang, B., Wang, D., Zhang, R., He, J., Meng, X., Wang, Z., Fan, H., Wen, T., Duan, D., Chen, L., Jiang, W., Lu, Y., Jiang, B., Wei, Y., Li, W., Yuan, Y., . . . Yan, X.. Nanozymes. Progres in Chemistry. 2023, 35(1), 1-87. Article 1005-281x(2023)35:1<1:Nmm>2.0.Tx;2-5. <Go to ISI>://CSCD:7419143
146. Fan, H., Zheng, J., Xie, J., Liu, J., Gao, X., Yan, X., Fan, K., & Gao, L.. Surface Ligand Engineering Ruthenium Nanozyme Superior to Horseradish Peroxidase for Enhanced Immunoassay. Advanced Materials. 2023: 2300387. https://doi.org/10.1002/adma.202300387
145. Ding, J., Luo, W., Wu, T., Cai, S., Zhang, Y., Li, H., Tu, B., Fang, Q., Yan, X., & Yang, R.. Atomic-thick porous Pd nanosheets with antioxidant enzyme-like activities and photothermal properties for potential Alzheimer’s disease treatment. Nano Today. 2023, 54. https://doi.org/10.1016/j.nantod.2023.102121
144. Chu, D., Qu, H., Huang, X., Shi, Y., Li, K., Lin, W., Xu, Z., Li, D., Chen, H., & Gao, L.. Manganese Amplifies Photoinduced ROS in Toluidine Blue Carbon Dots to Boost MRI Guided Chemo/Photodynamic Therapy. Small. 2023: 2304968. https://doi.org/10.1002/smll.202304968
143. Cheng, M., Xin, Q., Ma, S., Ge, M., Wang, F., Yan, X., & Jiang, B.. Advances in the Theranostics of Oesophageal Squamous Carcinoma. Advanced Therapeutics. 2023: 2200251. https://doi.org/10.1002/adtp.202200251
142. Chen, J., Xu, Q., Liu, D., Li, X., Guo, M., Chen, X., Liao, J., Lei, R., Li, W., Huang, H., Saw, P. E., Song, E., Yan, X., & Nie, Y.. CD146 promotes malignant progression of breast phyllodes tumor through suppressing DCBLD2 degradation and activating the AKT pathway. Cancer Communications. 2023, 43(11), 1244-1266. https://doi.org/10.1002/cac2.12495
141. Chen, J., Lu, J., Shan, Y., Wang, Y., Xu, Z., Xi, J., Fan, L., & Gao, L.. Manganese‐CpG Nanocomposite Integrates ROS‐Induced Cell Apoptosis and STING‐Activated and Adjuvant‐Augmented Immune Responses for Tumor Elimination and Prevention. Advanced Therapeutics. 2023, 6(3): 2200175. https://doi.org/10.1002/adtp.202200175
140. Cao, H., Wang, Q., Wang, X., Chen, L., Jiang, J., & Gao, L.. Metastable Iron Sulfides: A Versatile Antibacterial Candidate with Multiple Mechanisms against Bacterial Resistance. Accounts of Materials Research. 2023, 4(2), 115-132. https://doi.org/10.1021/accountsmr.2c00177
139. 范克龙, 高利增, 魏辉, 江冰, 王大吉, 张若飞, 贺久洋, 孟祥芹, 王卓然, & 樊慧真。 纳米酶。 化学进展。 2023， 35(1), 1. https://doi.org/10.7536/PC220833
138. Zare, I., Chevrier, D. M., Cifuentes-Rius, A., Moradi, N., Xianyu, Y., Ghosh, S., Trapiella-Alfonso, L., Tian, Y., Shourangiz-aghighi, A., Mukherjee, S., Fan, K., & Hamblin, M.. Protein-protected metal nanoclusters as diagnostic and therapeutic platforms for biomedical applications. Materials Today. 2023, 66, 159-193. https://doi.org/10.1016/j.mattod.2020.10.027
137. Zhu Daoming, Chen Hao, Huang Chunyu, Li Guoxin, Wang Xing, Jiang Wei, Fan Kelong. H2O2 Self‐Producing Single‐Atom Nanozyme Hydrogels as Light‐Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming “Cold” Tumors. Advanced Functional Materials. 2022, 32(16): 2110268. https://doi.org/10.1002/adfm.202110268
136. Zhou Caiyu, Wang Qian, Jiang Jing, Gao Lizeng. Nanozybiotics: Nanozyme-Based Antibacterials against Bacterial Resistance. Antibiotics. 2022, 11(3). https://doi.org/10.3390/antibiotics11030390
135. Zheng, X., Duan, Y., Pang, J., Feng, X., Gao, L., & Li, J.. Antibacterial effects of nano-decoction iron polysulfide in epididymitis and the systematic evaluation of its toxicity on the reproductive health of male mice. Ecotoxicology and Environmental Safety. 2022, 231. https://doi.org/10.1016/j.ecoenv.2022.113184
134. Zhang, Z., & Fan, K.. Bioorthogonal nanozymes: an emerging strategy for disease therapy. Nanoscale. 2022, 15(1), 41-62. https://doi.org/10.1039/d2nr05920g
133. Zhang Z., Conniot J., Amorim J., Jin Y., Prasad R., Yan X., Fan K., Conde J.. Nucleic acid-based therapy for brain cancer: Challenges and strategies. J Control Release. 2022, 350, 80-92. https://doi.org/10.1016/j.jconrel.2022.08.014
132. Zhang X., Zhang Y., Zhang R., Jiang X., Midgley A. C., Liu Q., Kang H., Wu J., Khalique A., Qian M., An D., Huang J., Ou L., Zhao Q., Zhuang J., Yan X., Kong D., Huang X.. Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues. Adv Mater. 2022: e2110352. https://doi.org/10.1002/adma.202110352
131. Zhang S., Zhang R., Yan X., Fan K.. Nanozyme-Based Artificial Organelles: An Emerging Direction for Artificial Organelles. Small. 2022, 18(33): e2202294. https://doi.org/10.1002/smll.202202294
130. Zhang, R., Zhao, H., & Fan, K.. Structure-Activity Mechanism of Iron Oxide Nanozymes. ACS Publications. 2022.
129. Zhang R., Xue B., Tao Y., Zhao H., Zhang Z., Wang X., Zhou X., Jiang B., Yang Z., Yan X., Fan K.. Edge-Site Engineering of Defective Fe-N4 Nanozymes with Boosted Catalase-Like Performance for Retinal Vasculopathies. Advanced Materials. 2022: e2205324. https://doi.org/10.1002/adma.202205324
128. Zhang Ronghan, Chen Xiaogang, Chen Shengwen, Tang Jiajia, Chen Feng, Lin Yong, Reinach Peter Sol, Yan Xiyun, Tu LiLi, Duan Hongxia. Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry. Cellular Oncology. 2022, 1-16. https://doi.org/10.1007/s13402-022-00682-9
127. Zhang B. L., Chen X. H., Tang G. H., Zhang R. F., Li J. Y., Sun G. M., Yan X. Y., Fan K. L.. Constructing a nanocage-based universal carrier for delivering TLR- activating nucleic acids to enhance antitumor immunotherapy. Nano Today. 2022, 46. https://doi.org/10.1016/j.nantod.2022.101564
126. Yu, F., Zhang, Q., Liu, H., Liu, J., Yang, S., Luo, X., Liu, W., Zheng, H., Liu, Q., & Cui, Y.. Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. Cell discovery. 2022, 8(1), 1-17. https://doi.org/101038/541421-022-003906
125. Yang Ji, Zhang Ruofei, Zhao Hanqing, Qi Haifeng, Li Jingyun, Li Jian‐Feng, Zhou Xinyao, Wang Aiqin, Fan Kelong, Yan Xiyun. Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment. Exploration. 2022, 2(4). https://doi.org/10.1002/EXP.20210267
124. Xue B., Ge M., Fan K., Huang X., Yan X., Jiang W., Jiang B., Yang Z.. Mitochondria-targeted nanozymes eliminate oxidative damage in retinal neovascularization disease. J Control Release. 2022, 350， 271-283. https://doi.org/10.1016/j.jconrel.2022.08.026
123. Xu Bolong, Li Shanshan, Zheng Lirong, Liu Yunhang, Han Along, Zhang Jin, Huang Zhijun, Xie Haijiao, Fan Kelong, Gao Lizeng. A Bioinspired Five‐Coordinated Single‐Atom Iron Nanozyme for Tumor Catalytic Therapy. Advanced Materials. 2022, 34(15): 2107088, https://doi.org/10.1002/adma.202107088
122. Xia Zihao, Gao Manman, Sheng Peng, Shen Mengmeng, Zhao Lin, Gao Lizeng, Yan Bingchun. Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice. International Journal of Molecular Sciences. 2022, 23(12): 126463. https://doi.org/10.3390/ijms23126463
121. Xi Juqun, Wang Yanqiu, Gao Xuejiao, Huang Yaling, Chen Jie, Chen Yong, Fan Lei, Gao Lizeng. Reverse intratumor bacteria-induced gemcitabine resistance with carbon nanozymes for enhanced tumor catalytic-chemo therapy. Nano Today. 2022, 43. https://doi.org/10.1016/j.nantod.2022.101395
120. Wu J., Wei Y., Lan J., Hu X., Gao F., Zhang X., Gao Z., Liu Q., Sun Z., Chen R., Zhao H., Fan K., Yan X., Zhuang J., Huang X.. Screening of Protein-Based Ultrasmall Nanozymes for Building Cell-Mimicking Catalytic Vesicles. Small. 2022, 18(39): e2202145. https://doi.org/10.1002/smll.202202145
119. Wei, Y., Wu, J., Wu, Y., Liu, H., Meng, F., Liu, Q., Midgley, A. C., Zhang, X., Qi, T., & Kang, H.. Prediction and Design of Nanozymes Using Explainable Machine Learning. Advanced Materials. 2022, 34(17). https://doi.org/10.1002/adma.202201736
118. Wang Z., Zhao Y., Zhang S., Chen X., Sun G., Zhang B., Jiang B., Yang Y., Yan X., Fan K.. Re-engineering the inner surface of ferritin nanocage enables dual drug payloads for synergistic tumor therapy， Theranostics. 2022, 12(4)，1800-1815. https://doi.org/10.7150/thno.68459
117. Wang Z., Liu Y., Peng L., Till B., Liao Y., Yuan S., Yan X., Chen L., Fu Q., Qin Z.. Role of fibrosarcoma-induced CD11b(+) myeloid cells and tumor necrosis factor-alpha in B cell responses. Oncogene. 2022, 41(10),1434-1444. https://doi.org/10.1038/s41388-022-02187-z
116. Wang Yanqiu, Chen Jie, Lu Jianxiu, Xi Juqun, Xu Zhilong, Fan Lei, Dai Hua, Gao Lizeng. Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference. Journal of Nanobiotechnology. 2022, 20(1), 1-14. https://doi.org/10.1186/s12951-022-01405-w
115. Wang, Q., Jin, Y., Jiang, J., & Gao, L.. Medical Devices Based on Nanozymes. ACS Publications. 2022.
114. Wang Qian, Jiang Jing, Gao Lizeng. Catalytic antimicrobial therapy using nanozymes. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology. 2022, 14(2): e1769. https://doi.org/10.1002/wnan.1769
113. Sun Z., Liu Q., Wang X., Wu J., Hu X., Liu M., Zhang X., Wei Y., Liu Z., Liu H., Chen R., Wang F., Midgley A. C., Li A., Yan X., Wang Y., Zhuang J., Huang X.. Bioorthogonal catalytic nanozyme-mediated lysosomal membrane leakage for targeted drug delivery. Theranostics. 2022, 12(3), 1132-1147. https://doi.org/10.7150/thno.66325
112. Pang Jing, Feng Xu, Liang Qian, Zheng Xiaoyan, Duan Yiman, Zhang Xin, Zhang Jubiao, Chen Yang, Fan Kelong, Gao Lizeng. Ferritin-Nanocaged ATP Traverses the Blood–Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model. ACS nano. 2022, 16(3), 4175-4185. https://doi.org/10.1021/acsnano.1c10029
111. Muhammad Pir, Hanif Sumaira, Li Jingyun, Guller Anna, Rehman Fawad Ur Muhammad, Ismail, Zhang Dongya, Yan Xiyun, Fan Kelong, Shi Bingyang. Carbon dots supported single Fe atom nanozyme for drug-resistant glioblastoma therapy by activating autophagy-lysosome pathway. Nano Today. 2022, 45. https://doi.org/10.1016/j.nantod.2022.101530
110. Mou, X., Wu, Q., Zhang, Z., Liu, Y., Zhang, J., Zhang, C., Chen, X., Fan, K., & Liu, H.. Nanozymes for Regenerative Medicine. Small Methods. 2022: e2200997. https://doi.org/10.1002/smtd.202200997
109. Meng, X., Zou, S., Li, D., He, J., Fang, L., Wang, H., Yan, X., Duan, D., & Gao, L.. Nanozyme-strip for rapid and ultrasensitive nucleic acid detection of SARS-CoV-2. Biosensors & Bioelectronics. 2022, 217. https://doi.org/10.1016/j.bios.2022.114739
108. Ma Ruonan, Fang Ling, Chen Lei, Wang Xiaonan, Jiang Jing, Gao Lizeng. Ferroptotic stress promotes macrophages against intracellular bacteria. Theranostics. 2022, 12(5), 2266-2289. https://doi.org/10.7150/thno.66663
107. Li, Q., Wu, T. T., Fan, X. W., Guo, X. B., Jiang, W., & Fan, K. L., Multifaceted nanozymes for synergistic antitumor therapy: A review, Materials & Design. 2022, 224. https://doi.org/10.1016/j.matdes.2022.111430
106. Jiang B., Jia X., Ji T., Zhou M., He J., Wang K., Tian J., Yan X., Fan K.. Ferritin nanocages for early theranostics of tumors via inflammation-enhanced active targeting. Science China-Life Sciences. 2022, 65(2), 328-340. https://doi.org/10.1007/s11427-021-1976-0
105. Hong Chaoyi, Meng Xiangqin, He Jiuyang, Fan Kelong, Yan Xiyun. Nanozyme: A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment. Particuology. 2022, 90-107. https://doi.org/10.1016/j.partic.2022.02.001
104. He, H., Fei, Z., Guo, T., Hou, Y., Li, D., Wang, K., Ren, F., Fan, K., Zhou, D., Xie, C., Wang, C., & Lu, X.. Bioadhesive injectable hydrogel with phenolic carbon quantum dot supported Pd single atom nanozymes as a localized immunomodulation niche for cancer catalytic immunotherapy. Biomaterials. 2022, 280: 121272. https://doi.org/10.1016/j.biomaterials.2021.121272
103. Gao, L., Chen, L., Zhang, R., & Yan, X.. Nanozymes: next-generation artificial enzymes. Scientia Sinica Chimica. 2022, 52(9), 1649-1663. Accession Number: CSCD:7359626
102. Fang Ling, Ma Ruonan, Gao Xuejiao J, Chen Lei, Liu Yuan, Huo Yanwu, Wei Taotao, Wang Xiaonan, Wang Qian, Wang Haojue, Cui Chengjun, Shi Qifeng,Jiang Jing,Gao Lizeng. Metastable Iron Sulfides Gram‐Dependently Counteract Resistant Gardnerella Vaginalis for Bacterial Vaginosis Treatment. Advanced Science. 2022, 9(10). https://doi.org/10.1002/advs.202104341
101. Ding, H., Wang, D., Huang, H., Chen, X., Wang, J., Sun, J., Zhang, J., Lu, L., Miao, B., & Cai, Y.. Black phosphorus quantum dots as multifunctional nanozymes for tumor photothermal/catalytic synergistic therapy. Nano Research. 2022, 15(2)， 1554-1563. https://doi.org/10.1007/s12274-021-3701-8
100. Chen, Y., Zeng, L., Zhu, H., Wu, Q., Liu, R., Liang, Q., Chen, B., Dai, H., Tang, K., Liao, C., Huang, Y., Yan, X., Fan, K., Du, J.-Z., Lin, R., & Wang, J.. Ferritin Nanocaged Doxorubicin Potentiates Chemo-Immunotherapy against Hepatocellular Carcinoma via Immunogenic Cell Death. Small Methods. 2022. https://doi.org/10.1002/smtd.202201086
99. Chen, Y., Tian, Q., Wang, H., Ma, R., Han, R., Wang, Y., Ge, H., Ren, Y., Yang, R., Yang, H., Chen, Y., Duan, X., Zhang, L., Gao, J., Gao, L., Yan, X., & Qin, Y.. A Manganese-Based Metal-Organic Framework as a Cold-Adapted Nanozyme. Advanced Materials. 2022. https://doi.org/10.1002/adma.202206421
98. Chen, J., Lu, J., Shan, Y., Wang, Y., Xu, Z., Xi, J., Fan, L., & Gao, L.. Manganese-CpG Nanocomposite Integrates ROS-Induced Cell Apoptosis and STING-Activated and Adjuvant-Augmented Immune Responses for Tumor Elimination and Prevention. Advanced Therapeutics. 2022. https://doi.org/10.1002/adtp.202200175
97. Duan Hongxia, Jing Lin, Xiang Jianquan, Ju Chenhui, Wu Zhenzhen, Liu Jingyu, Ma Xinran, Chen Xuehui, Liu Zheng, Feng Jing, Yan Xiyun. CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity. Advanced Science. 2022, 9(13): 2103719. https://doi.org/10.1002/advs.202103719
96. Zhao Hanqing, Zhang Ruofei, Yan Xiyun, Fan Kelong. Superoxide dismutase nanozymes: an emerging star for anti-oxidation. Journal of Materials Chemistry B. 2021, 9(35): 6939-6957. https://doi.org/10.1039/d1tb00720c
95. Zhang Ruofei, Chen Lei, Liang Qian, Xi Juqun, Zhao Hanqing, Jin Yiliang, Gao Xingfa, Yan Xiyun, Gao Lizeng, Fan Kelong. Unveiling the active sites on ferrihydrite with apparent catalase-like activity for potentiating radiotherapy. Nano Today. 2021, 41. https://doi.org/10.1016/j.nantod.2021.101317
94. Zhang, J., Cheng, D., He, J., Hong, J., Yuan, C., & Liang, M.. Cargo loading within ferritin nanocages in preparation for tumor-targeted delivery. Nature Protocols Erecipes for Researchers. 2021, 16(10), 4878-4896. https://www.nstl.gov.cn/paper_detail.html?id=62e0680e81fcf8f729651f514dfd0a4e
93. Jianlin Zhang, Xuehui Chen, Juanji Hong, Aifa Tang, Yang Liu, Ni Xie, Guohui Nie, Xiyun Yan, and Minmin Liang. Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses. Science China-Life Sciences. 2021, 64（3）, 352-362. http://dx.doi.org/10.1007/s11427-020-1795-4
92. Zhang Baoli, Tang Guoheng, He Jiuyang, Yan Xiyun, Fan Kelong. Ferritin nanocage: a promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier. Advanced Drug Delivery Reviews. 2021, 176: 113892. https://doi.org/10.1016/j.addr.2021.113892
91. Yan, B. C., Cao, J., Liu, J., Gu, Y., Xu, Z., Li, D., & Gao, L.. Dietary Fe<sub>3</sub>O<sub>4</sub> Nanozymes Prevent the Injury of Neurons and Blood-Brain Barrier Integrity from Cerebral Ischemic Stroke. Acs Biomaterials Science & Engineering. 2021, 7(1), 299-310. https://doi.org/10.1021/acsbiomaterials.0c01312
90. Xue Bai, Wang Ping, Yu Wenzhen, Feng Jing, Li Jie, Zhao Rulian, Yang Zhenglin, Yan Xiyun, Duan Hongxia. CD146 as a promising therapeutic target for retinal and choroidal neovascularization diseases. Science China-Life Sciences. 2021, 1-14. https://doi.org/10.1007/s11427-021-2020-0
89. Wu Chunling, Shi Huigang, Zhu Dongjie, Fan Kelong, Zhang Xinzheng. Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames. QRB Discovery. 2021, 2. https://doi.org/10.1017/qrd.2021.8
88. Wei Hui, Gao Lizeng, Fan Kelong, Liu Juewen, He Jiuyang, Qu Xiaogang, Dong Shaojun, Wang Erkang, Yan Xiyun. Nanozymes: A clear definition with fuzzy edges. Nano Today. 2021, 40: 101269. https://doi.org/10.1016/j.nantod.2021.101269
87. Wang Daji, Zhang Bin, Ding Hui, Liu Dan, Xiang Jianquan, Gao Xuejiao J, Chen Xuehui, Li Zhongjun, Yang Lei, Duan Hongxia. TiO2 Supported Single Ag Atoms Nanozyme for Elimination of SARS-CoV2. Nano today. 2021. https://doi.org/10.1016/j.nantod.2021.101243
86. Tian Qing, Yang Yingchun, Li Aipeng, Chen Yao, Li Yixiao, Sun Leming, Shang Li, Gao Lizeng, Zhang Lianbing. Ferrihydrite Nanoparticles as the Photosensitizer Augment Microbial Infected Wound Healing with Blue light. Nanoscale. 2021, 13(45), 19123-19132. https://doi.org/10.1039/D1NR05364G
85. Tang Guoheng, He Jiuyang, Liu Juewen, Yan Xiyun, Fan Kelong. Nanozyme for tumor therapy: Surface modification matters. Exploration. 2021, 1(1), 75-89. https://doi.org/10.1002/EXP.20210005
84. Qingzhi Wu, Zou Sijia, Wang Qian, Chen Lei, Yan Xiyun, Gao Lizeng. Catalytic defense against fungal pathogens using nanozymes. Nanotechnology Reviews. 2021, 10(1), 1277-1292. https://doi.org/10.1515/ntrev-2021-0084
83. Hu, X., Wang, X., Liu, Q., Wu, J., Zhang, H., Khalique, A., Sun, Z., Chen, R., Wei, J., & Li, H.. Nanozyme-Powered Giant Unilamellar Vesicles for Mimicry and Modulation of Intracellular Oxidative Stress. ACS Applied Materials & Interfaces. 2021, 13(18), 21087-21096, https://doi.org/10.1021/acsami.1c05512
82. Hongxia Duan, Shuai Zhao, Jianquan Xiang, Chenhui Ju, Xuehui Chen, Irene Gramaglia, and Xiyun Yan. Targeting the CD146/Galectin-9 axis protects the integrity of the blood-brain barrier in experimental cerebral malaria. Cellular & Molecular Immunology. 2021. http://dx.doi.org/10.1038/s41423-020-00582-8
81. Duan H., Jing L., Jiang X., Ma Y., Wang D., Xiang J., Chen X., Wu Z., Yan H., Jia J., Liu Z., Feng J., Zhu M., Yan X.. CD146 bound to LCK promotes T cell receptor signaling and antitumor immune responses in mice. The Journal of Clinical Investigation. 2021, 131(21): e148568, https://doi.org/10.1172/JCI148568
80. 赵越, 孟祥芹, 阎锡蕴, 范克龙. 纳米酶: 一种新型的生物安全材料. 应用化学. 2021, 38(5), 524. https://doi.org/10.19894/j.issn.10000518.21017
79. Xiaohang Chen, Helin Xing, Zilan Zhou, Yujia Hao, Xiaoxuan Zhang, Feng Qi, Jing Zhao, Lizeng Gao and Xing Wang. Nanozymes go oral: nanocatalytic medicine facilitates dental health. Journal of Materials Chemistry B. 2021, 9(6), 1491-1502. https://doi.org/10.1039/D0TB02763D
78. Xuehui Chen, Huiwen Yan, Dan Liu, Qingji Xu, Hongxia Duan, Jing Feng, Xiyun Yan, Can Xie. Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146. Iscience. 2021, 24(5): 102417. https://doi.org/10.1016/j.isci.2021.102417
77. Jia, Z., Lv, X., Hou, Y., Wang, K., Ren, F., Xu, D., Wang, Q., Fan, K., Xie, C., & Lu, X.. Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics. Bioactive materials. 2021, 23, 524-525. https://doi.org/10.1016/j.bioactmat.2022.11.021
76. Shufang Ji, Bing Jiang, Haigang Hao, Yuanjun Chen, Juncai Dong, Yu Mao, Zedong Zhang, Rui Gao, Wenxing Chen, Ruofei Zhang, Qian Liang, Haijing Li, Shuhu Liu, Yu Wang, Qinghua Zhang, Lin Gu, Demin Duan, Minmin Liang, Dingsheng Wang, Xiyun Yan & Yadong Li. Matching the kinetics of natural enzymes with a single-atom iron nanozyme. Nature Catalysis. 2021, 4(5), 407-417. https://doi.org/10.1038/s41929-021-00609-x
75. Qian Wang, Jing Jiang and Lizeng Gao. Nanozyme-based medicine for enzymatic therapy: progress and challenges. Biomedical Materials. 2021, 16(4). https://iopscience.iop.org/article/10.1088/1748-605X/abe7b4
74. Zhuoran Wang, Shuai Zhang, Ruofei Zhang, Xuehui Chen, Guoming Sun, Meng Zhou, Qiubai Han, Baoli Zhang, Yue Zhao, Bing Jiang, Yili Yang, Xiyun Yan, Kelong Fan. Bioengineered Dual‐Targeting Protein Nanocage for Stereoscopically Loading of Synergistic Hydrophilic/Hydrophobic Drugs to Enhance Anticancer Efficacy. Advanced Functional Materials. 2021. https://doi.org/10.1002/adfm.202102004
73. Juqun Xi, Lanfang An, Yaling Huang, Jian Jiang, Yanqiu Wang, Gen Wei, Zhilong Xu, Lei Fan, Lizeng Gao. Ultrasmall FeS2 Nanoparticles‐Decorated Carbon Spheres with Laser‐Mediated Ferrous Ion Release for Antibacterial Therapy. Small. 2021, 17(13): 2005473. https://doi.org/10.1002/smll.202005473
72. Xi, J., Huang, Y., Chen, J., Zhang, J., Gao, L., Fan, L., & Qian, X.. Artesunate-loaded poly (lactic-<i>co</i>-glycolic acid)/polydopamine-manganese oxides nanoparticles as an oxidase mimic for tumor chemo-catalytic therapy. International Journal of Biological Macromolecules. 2021, 181, 72-81. https://doi.org/10.1016/j.ijbiomac.2021.03.124
71. Kaleemullah kalwar, Juqun Xi, Li Dandan, Lizeng Gao. Fabrication of PAN/FeNPs electrospun nanofibers: Nanozyme and an efficient antimicrobial agent. Materials Today Communications. 2021, 26: 102168. https://doi.org/10.1016/j.mtcomm.2021.102168
70. Jianlin Zhang, Shimin Li, Ni Xie, Guohui Nie, Aifa Tang, Xian-En Zhang, Minmin Liang & Xiyun Yan. A natural nanozyme in life is found: the iron core within ferritin shows superoxide dismutase catalytic activity. Science China-Life Sciences. 2021, 1-4. https://doi.org/10.1007/s11427-020-1865-2
69. Ruofei Zhang, Xiyun Yan, and Kelong Fan. Nanozymes Inspired by Natural Enzymes. Accounts of Materials Research. 2021, 2(7), 534-547. https://doi.org/10.1021/accountsmr.1c00074
68. Yanan Zhang, Yingni Li, Jianlin Zhang, Xuehui Chen, Ruofei Zhang, Guoming Sun, Bing Jiang, Kelong Fan, Zhanguo Li, Xiyun Yan. Nanocage‐Based Capture‐Detection System for the Clinical Diagnosis of Autoimmune Disease. Small. 2021: 2101655. https://doi.org/10.1002/smll.202101655
67. Hanqing Zhao, Ruofei Zhang, Xiyun Yan and Kelong Fan. Superoxide dismutase nanozyme: an emerging star for anti-oxidation. Journal of Materials Chemistry B. 2021， 9(35), 6939-6957. https://doi.org/10.1039/d1tb00720c
66. Lipeng Zhu, Yunlu Dai, Lizeng Gao, Qi Zhao. Tumor Microenvironment-Modulated Nanozymes for NIR-II-Triggered Hyperthermia-Enhanced Photo-Nanocatalytic Therapy via Disrupting ROS Homeostasis. International Journal of Nanomedicine. 2021,16,4559-4577. https://doi.org/10.2147/IJN.S309062
65. Yan Zu, Huiqin Yao, Yifan Wang, Liang Yan, Zhanjun Gu, Chunying Chen, Lizeng Gao, Wenyan Yin. The age of bioinspired molybdenum-involved nanozymes: Synthesis, catalytic mechanisms, and biomedical applications. View. 2021. https://doi.org/10.1002/VIW.20200188
64. Yue Zhang, Anila Khalique, Xinchen Du, Zhanxia Gao, Jin Wu, Xiangyun Zhang, Ran Zhang, Zhiyuan Sun, Qiqi Liu, Zhelong Xu, Adam C. Midgley, Lianyong Wang, Xiyun Yan, Jie Zhuang, Deling Kong, and Xinglu Huang. Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers. Advanced Materials. 2021. 33(9). http://dx.doi.org/10.1002/adma.202006570
63. Xia, X., Shi, B., Wang, L., Liu, Y., Zou, Y., Zhou, Y., Chen, Y., Zheng, M., Zhu, Y., & Duan, J.. From mouse to mouse‐ear cress: Nanomaterials as vehicles in plant biotechnology. Exploration. 2021， 9-20. Publisher: Wiley Online Library
62. Juqun Xi, Ruofei Zhang, Liming Wang, Wei Xu, Qian Liang, Jingyun Li, Jian Jiang, Yili Yang, Xiyun Yan, Kelong Fan, and Lizeng Gao. A Nanozyme-Based Artificial Peroxisome Ameliorates Hyperuricemia and Ischemic Stroke. Advanced Functional Materials. 2021, 31(9). http://dx.doi.org/10.1002/adfm.202007130
61. Zhenzhen Wu, Jingyu Liu, Gang Chen, Junfeng Du, Huiyun Cai, Xuehui Chen, Gaoqi Ye, Yongting Luo, Yiyi Luo, Liwen Zhang, Hongxia Duan, Zheng Liu, Sai Yang, Hongwei Sun, Yan Cui, Lei Sun, Hongjie Zhang, Guizhi Shi, Taotao Wei, Pingsheng Liu, Xiyun Yan, Jing Feng, and Pengcheng Bu. CD146 is a Novel ANGPTL2 Receptor that Promotes Obesity by Manipulating Lipid Metabolism and Energy Expenditure. Advanced Science. 2021, 8(6). http://dx.doi.org/10.1002/advs.202004032
60. Xiangqin Meng, Dandan Li, Lei Chen, Helen He, Qian Wang, Chaoyi Hong, Jiuyang He, Xingfa Gao, Yili Yang, Bing Jiang, Guohui Nie, Xiyun Yan, Lizeng Gao, and Kelong Fan. High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis-Ferroptosis Synergistic Tumor Therapy. ACS nano. 2021, 15(3),5735-5751, http://dx.doi.org/10.1021/acsnano.1c01248
59. Liu, Q., Tian, J., Liu, J., Zhu, M., Gao, Z., Hu, X., Midgley, A. C., Wu, J., Wang, X., & Kong, D.. Modular Assembly of Tumor‐Penetrating and Oligomeric Nanozyme Based on Intrinsically Self‐Assembling Protein Nanocages. Advanced Materials. 2021, 33(39): 2103128. https://doi.org/10.1002/adma.202103128
58. Dan Liu, Chenhui Ju, Chao Han, Rui Shi, Xuehui Chen, Demin Duan, Jinghua Yan, and Xiyun Yan. Nanozyme chemiluminescence paper test for rapid and sensitive diagnosis of SARS-CoV-2 infection. Biosensors & Bioelectronics. 2021, 173.
http://dx.doi.org/10.1016/j.bios.2020.112817
57. Liming Ding, Jiang Jian, Cheng Lu, Wang Yanqiu, Zhang Wei, Li Dandan, Xu Zhuobin, Jiang Jing, Gao Lizeng, Li Zhennan. Oral administration of nanoiron sulfide supernatant for the treatment of gallbladder stones with chronic cholecystitis. ACS Applied Bio Materials. 2021, 4(5), 3773-3785. https://doi.org/10.1021/acsabm.0c01258
56. Hui Ding, Bing Hu, Bin Zhang, Han Zhang, Xiyun Yan, Guohui Nie, and Minmin Liang. Carbon-based nanozymes for biomedical applications. Nano Research. 2021, 14(3), 570-583. http://dx.doi.org/10.1007/s12274-020-3053-9
55. Prof. Feng Li, Shuai Li, Xiaocui Guo, Yuhang Dong, Dr. Chi Yao, Prof. Yangping Liu, Dr. Yuguang Song, Dr. Xiaoli Tan, Prof. Lizeng Gao, Prof. Dayong Yang. Chiral Carbon Dots Mimicking Topoisomerase I to Mediate the Topological Rearrangement of Supercoiled DNA Enantioselectively. Angewandte Chemie. 2020, 132 (27), 11180-11185. https://doi.org/10.1002/ange.202002904
54. Yiru Shen, Yunqi Xiao, Shan Zhang, Shu Wu, Lizeng Gao and Shourong Shi. Fe3o4 Nanoparticles Attenuated Salmonella Infection in Chicken Liver through Reactive Oxygen and Autophagy Via Pi3k/Akt/Mtor Signaling. Frontiers in physiology. 2020, 10: 01580. https://doi.org/10.3389/fphys.2019.01580
53. Wang, H., Fang, L., Cui, C., Shi, Q., Lu, S., Lu, X., & Gao, L.. In vitro inhibitory effect of Fe_3O_4 nanozymes against Candida albicans. Chinese Journa of Dermatology. 2020, 53(7), 554-556. Accession Number: CSCD:6759003
52. Huihui Wang, Lu Cheng, Shang Ma, Liming Ding, Wei Zhang, Zhuobin Xu, Dandan Li, and Lizeng Gao. Self-Assembled Multiple-Enzyme Composites for Enhanced Synergistic Cancer Starving–Catalytic Therapy. ACS applied materials & interfaces. 2020, 12 (18), 20191-20201. https://doi.org/10.1021/acsami.0c02006
51. Ye Yuan, Liping Wang and Lizeng Gao. Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications. Frontiers in Chemistry. 2020, 8: 00818. http://doi.org/10.3389/fchem.2020.00818
50. Zhang, X., Xing, H., Qi, F., Liu, H., Gao, L., & Wang, X.. Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects. Nanotheranostics. 2020, 4(4), 242-255. https://doi.org/10.7150/ntno.46408
49. Shan Zhang, Shu Wu, Yiru Shen, Yunqi Xiao, Lizeng Gao and Shourong Shi. Cytotoxicity Studies of Fe3o4 Nanoparticles in Chicken Macrophage Cells. Royal Society open science. 2020, 7 (4), 191561. https://doi.org/10.1098/rsos.200641
48. Zhou, S., Liang, D., Wang, X., Yu, F., Su, X., Gao, L., & Zhu, X.. Vitamin B_2 Modified IONzymes Against Oxidative Stress Injury in HaCaT Cells Induced by Ultraviolet. The Chinese Journal of Dermatovenereology. 34(10), 1099-1103. Accession Number: CSCD:6826135
47. Yanan Zhang, Yiliang Jin, Haixia Cui, Xiyun Yan, and Kelong Fan. Nanozyme-based catalytic theranostics. Rsc Advances. 2020. 10(1), 10-20, http://dx.doi.org/10.1039/c9ra09021e
46. Ruofei Zhang, Kelong Fan, and Xiyun Yan. Nanozymes: created by learning from nature. Science China-Life Sciences. 2020. 63(8), 1183-1200. http://dx.doi.org/10.1007/s11427-019-1570-7
45. Yang Yang, Daoming Zhu, Ying Liu, Bing Jiang, Wei Jiang, Xiyun Yan, and Kelong Fan. Platinum-carbon-integrated nanozymes for enhanced tumor photodynamic and photothermal therapy. Nanoscale. 2020, 12(25), 13548-13557. http://dx.doi.org/10.1039/d0nr02800b
44. Zhuoran Wang, Ruofei Zhang, Xiyun Yan, and Kelong Fan. Structure and activity of nanozymes: Inspirations for de novo design of nanozymes. Materials Today. 2020, 41, 81-119. http://dx.doi.org/10.1016/j.mattod.2020.08.020
43. Zhaoqing Wang, Qingji Xu, Nengwei Zhang, Xuemei Du, Guangzhong Xu, and Xiyun Yan. CD146, from a melanoma cell adhesion molecule to a signaling receptor. Signal Transduction and Targeted Therapy. 2020, 5(1), 148. http://dx.doi.org/10.1038/s41392-020-00259-8
42. Wenjun Wang, Xiaoxiao Zhou, Yingjie Bian, Shan Wang, Qian Chai, Zhenqian Guo, Zhenni Wang, Ping Zhu, Hua Peng, Xiyun Yan, Wenhui Li, Yang-Xin Fu, and Mingzhao Zhu. Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B. Nature Nanotechnology. 2020, 15(5). http://dx.doi.org/10.1038/s41565-020-0648-y
41. Peixia Wang, Tao Wang, Juanji Hong, Xiyun Yan, and Minmin Liang. Nanozymes: A New Disease Imaging Strategy. Frontiers in Bioengineering and Biotechnology. 2020, 8(15). http://dx.doi.org/10.3389/fbioe.2020.00015
40. Peixia Wang, Shili Liu, Mingxiang Hu, Hongwei Zhang, Demin Duan, Jiuyang He, Juanji Hong, Ruitao Lv, Hak Soo Choi, Xiyun Yan, and Minmin Liang. Peroxidase-Like Nanozymes Induce a Novel Form of Cell Death and Inhibit Tumor Growth In Vivo. Advanced Functional Materials. 2020, 30(21). http://dx.doi.org/10.1002/adfm.202000647
39. Daji Wang, Hongxia Duan, Jing Feng, Jianquan Xiang, Liqun Feng, Dan Liu, Xuehui Chen, Lin Jing, Zheng Liu, Dexi Zhang, Hongjun Hao, and Xiyun Yan. Soluble CD146, a cerebrospinal fluid marker for neuroinflammation, promotes blood-brain barrier dysfunction. Theranostics. 2020, 10(1), 231-246. http://dx.doi.org/10.7150/thno.37142
38. Xinyu Shen, Ma Ruonan, Huang Yixin, Chen Lei, Xu Zhuobin, Li Dandan, Meng Xiangqin, Fan Kelong, Xi Juqun, Yan Xiyun, Koo Hyun, Yang Yili, Jiang Jing, and Gao Lizeng. Nano-decocted ferrous polysulfide coordinates ferroptosis-like death in bacteria for anti-infection therapy. Nano Today. 2020, 35. http://dx.doi.org/10.1016/j.nantod.2020.100981
37. Xiangqin Meng, Iman Zare, Xiyun Yan, and Kelong Fan. Protein-protected metal nanoclusters: An emerging ultra-small nanozyme. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology. 2020, 12(3). http://dx.doi.org/10.1002/wnan.1602
36. Qian Liang, Juqun Xi, Xuejiao J. Gao, Ruofei Zhang, Yili Yang, Xingfa Gao, Xiyun Yan, Lizeng Gao, and Kelong Fan. A metal-free nanozyme-activated prodrug strategy for targeted tumor catalytic therapy. Nano Today. 2020, 35. http://dx.doi.org/10.1016/j.nantod.2020.100935
35. Bing Jiang, Long Fang, Kongming Wu, Xiyun Yan, and Kelong Fan. Ferritins as natural and artificial nanozymes for theranostics. Theranostics. 2020, 10(2), 687-706. http://dx.doi.org/10.7150/thno.39827
34. Bing Jiang, Xuehui Chen, Guoming Sun, Xiangru Chen, Yufang Yin, Yiliang Jin, Qian Mi, Long Ma, Yili Yang, Xiyun Yan, and Kelong Fan. A natural drug entry channel in the ferritin nanocage. Nano Today. 2020, 35. http://dx.doi.org/10.1016/j.nantod.2020.100948
33. Xiaohua Jia, Kelong Fan, Ruofei Zhang, Dan Zhang, Jianjun Zhang, Yuan Gao, Tao Zhang, Wanjun Li, Junlai Li, Xiyun Yan, and Jie Tian. Precise visual distinction of brain glioma from normal tissues via targeted photoacoustic and fluorescence navigation. Nanomedicine-Nanotechnology Biology and Medicine. 2020. http://dx.doi.org/10.1016/j.nano.2020.102204
32. Xi Hu, Fangyuan Li, Fan Xia, Xia Guo, Nan Wang, Lili Liang, Bo Yang, Kelong Fan, Xiyun Yan, and Daishun Ling. Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy. Journal of the American Chemical Society. 2020, 142(3),1636-1644. http://dx.doi.org/10.1021/jacs.9b13586
31. Tao Qin, Ma Shang, Miao Xinyu, Tang Yan, Huangfu Dandan, Wang Jinyuan, Jiang Jing, Xu Nuo, Yin Yuncong, Chen Sujuan, Liu Xiufan, Yin Yinyan, Peng Daxin, Gao Lizeng. Mucosal Vaccination for Influenza Protection Enhanced by Catalytic Immune-Adjuvant. Advanced Science. 2020, 7(18): 2000771. https://doi.org/10.1002/advs.202000771
30. Yanqiu Wang, Shen Xinyu, Ma Shang, Guo Qianqian, Zhang Wei, Cheng Lu, Ding Liming, Xu Zhuobin, Jiang Jing Gao Lizeng. Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria. Biomaterials Science. 2020, 8(9), 2447-2458. https://doi.org/10.1039/C9BM01889A
29. Dandan Li, Guo Qianqian, Ding Liming, Zhang Wei, Cheng Lu, Wang Yanqiu, Xu Zhuobin, Wang Huihui, Gao Lizeng. Bimetallic CuCo2S4 nanozymes with enhanced peroxidase activity at neutral pH for combating burn infections. ChemBioChem. 2020, 21(18), 2620-2627. https://doi.org/10.1002/cbic.202000066
28. Juqun Xi, An Lanfang, Wei Gen, Huang Yaling, Li Dandan, Fan Lei, Gao Lizeng. Photolysis of methicillin-resistant staphylococcus aureus using cu-doped carbon spheres. Biomaterials Science. 2020, 8(22), 6225-6234. https://doi.org/10.1039/D0BM01239D
27. Jiaying Xie,Yiliang Jin,Kelong Fan,Xiyun Yan. The prototypes of nanozyme-based nanorobots. Biophysics Reports. 2020. 6(6), 223-244. https://doi.org/10.1007/s41048-020-00125-8
26. Gu, Y., Huang, Y., Qiu, Z., Xu, Z., Li, D., Chen, L., Jiang, J., & Gao, L.. Vitamin B<sub>2</sub> functionalized iron oxide nanozymes for mouth ulcer healing. Science China-Life Sciences. 2020, 63(1), 68-79. https://doi.org/10.1007/s11427-019-9590-6
25. Gao, L., Wei, H., & Qu, X.. Current developments and trends in nanobiocatalysis. Scientia Sinica Vitae. 2020, 50(7), 682-697. Accession Number: CSCD:6807841
24. Ehigie, A. F., Wei, P., Wei, T., Yan, X., Ojeniyi, F. D., & Ehigie, L. O.. Treatment with Momordica charantia Fractions Disrupts Energy Metabolism and Elevated Reactive Oxygen Species’ Generation in Human Lung and Breast Cancer Cell Lines. The FASEB Journal. 2020, 34(S1): 1-1. https://doi.org/10.1096/fasebj.2020.34.s1.00276
23. Cheng, X., Fan, K., Wang, L., Ying, X., Sanders, A. J., Guo, T., Xing, X., Zhou, M., Du, H., Hu, Y., Ding, H., Li, Z., Wen, X., Jiang, W., Yan, X., & Ji, J.. TfR1 binding with H-ferritin nanocarrier achieves prognostic diagnosis and enhances the therapeutic efficacy in clinical gastric cancer. Cell Death & Disease. 2020，11(2),92. https://doi.org/10.1038/s41419-020-2272-z
22. Tao Qin， Ma Ruonan， Yin Yinyan， Miao Xinyu， Chen Sujuan， Fan Kelong， Xi Juqun, Liu Qi, Gu Yunhao, Yin Yuncong, Hu Jiao, Liu Xiufan, Peng, Daxin, Gao Lizeng. Catalytic inactivation of influenza virus by iron oxide nanozyme. Theranostics. 2019, 9(23), 6920-6935. http://dx.doi.org/10.7150/thno.35826
21. Zhao Shuai, Hongxia Duan, Yili Yang, Xiyun Yan, and Kelong Fan. Fenozyme protects the integrity of the blood-brain barrier against experimental cerebral malaria. Nano Letters. 2019, 19(12), 8887-8895. http://dx.doi.org/10.1021/acs.nanolett.9b03774
20. Ruofei Zhang, Yunlong Zhou, Xiyun Yan, and Kelong Fan. Advances in chiral nanozymes: a review. Microchimica Acta. 2019, 186(12), 782. http://dx.doi.org/10.1007/s00604-019-3922-7.
19. Zhang, R., Yan, X., & Fan, K.. The Advances of Nanozyme in Brain Disease, Springer. 2019, 139-179. https://link.springer.com/chapter/10.1007/978-981-13-8731-9_6
18. Zhang, C., Du, C., Liao, J.-Y., Gu, Y., Gong, Y., Pei, J., Gu, H., Yin, D., Gao, L., & Pan, Y.. Synthesis of magnetite hybrid nanocomplexes to eliminate bacteria and enhance biofilm disruption. Biomaterials science. 2019，7(7), 2833-2840. https://doi.org/10.1039/C9BM00057G
17. Yin, Y.-Y., Wu, M.-X., Qin, T., He, K.-M., Xu, N., Shi, Y., Liu, Q., Peng, D.-X., & Gao, L.-Z.. Effects of Iron-based Nanozymes on S. <i>typhimurium</i> Biofilm. Progress in Biochemistry and Biophysics. 2019, 46(6), 587-595. https://doi.org/10.16476/j.pibb.2019.0024
16. Bolong Xu, Hui Wang, Weiwei Wang, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang, Hailong Yang, Xiangqin Meng, Qiuwen Wu, Lirong Zheng, Shenming Chen, Xinghua Shi, Kelong Fan, Xiyun Yan, and Huiyu Liu. A single-atom nanozyme for wound disinfection applications. Angewandte Chemie-International Edition. 2019, 58(15), 4911-4916. http://dx.doi.org/10.1002/anie.201813994
15. Xi, J., Wei, G., Wu, Q., Xu, Z., Liu, Y., Han, J., Fan, L., & Gao, L.. Light-enhanced sponge-like carbon nanozyme used for synergetic antibacterial therapy. Biomaterials science. 2019, 7(10), 4131-4141. https://doi.org/10.1039/C9BM00705A
14. Xi, J., Wei, G., An, L., Xu, Z., Xu, Z., Fan, L., & Gao, L.. Copper/carbon hybrid nanozyme: tuning catalytic activity by the copper state for antibacterial therapy. Nano letters. 2019, 19(11), 645-7654. https://doi.org/10.1021/acs.nanolett.9b0224
13. Tao Wang, Jiuyang He, Demin Duan, Bing Jiang, Peixia Wang, Kelong Fan, Minmin Liang, and Xiyun Yan, Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans. Nano Research. 2019, 12(4), 863-868. http://dx.doi.org/10.1007/s12274-019-2313-z
12. Naha, P. C., Liu, Y., Hwang, G., Huang, Y., Gubara, S., Jonnakuti, V., Simon-Soro, A., Kim, D., Gao, L., & Koo, H.. Dextran-coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption. Acs Nano. 2019, 13(5), 4960-4971.https://doi.org/10.1021/acsnano.8b08702
11. Xiangqin Meng, Kelong Fan, and Xiyun Yan. Nanozymes: an emerging field bridging nanotechnology and enzymology. Science China-Life Sciences. 2019, 62(11), 1543-1546. http://dx.doi.org/10.1007/s11427-019-1557-8
10. Yongting Luo, Xiao Teng, Lingling Zhang, Jianan Chen, Zheng Liu, Xuehui Chen, Shuai Zhao, Sai Yang, Jing Feng, and Xiyun Yan. CD146-HIF-1alpha hypoxic reprogramming drives vascular remodeling and pulmonary arterial hypertension. Nature Communications. 2019, 10, 1-17, http://dx.doi.org/10.1038/s41467-019-11500-6
9. Minmin Liang and Xiyun Yan. Nanozymes: from new concepts, mechanisms, and standards to applications. Accounts of Chemical Research. 2019, 52(8), 2190-2200. http://dx.doi.org/10.1021/acs.accounts.9b00140
8. Yiliang Jin, Jiuyang He, Kelong Fan, and Xiyun Yan. Ferritin variants: inspirations for rationally designing protein nanocarriers. Nanoscale. 2019, 11(26), 12449-12459. http://dx.doi.org/10.1039/c9nr03823j
7. Dawei Jiang, Dalong Ni, Zachary T. Rosenkrans, Peng Huang, Xiyun Yan, and Weibo Cai. Nanozyme: new horizons for responsive biomedical applications. Chemical Society Reviews. 2019, 48(14), 3677-3998. http://dx.doi.org/10.1039/c8cs00718g
6. Bing Jiang, Ruofei Zhang, Jianlin Zhang, Yaxin Hou, Xuehui Chen, Meng Zhou, Xiuyun Tian, Chunyi Hao, Kelong Fan, and Xiyun Yan. GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy. Theranostics. 2019, 9(8), 2167-2182, http://dx.doi.org/10.7150/thno.30867
5. Bing Jiang, Liang Yan, Jianlin Zhang, Meng Zhou, Guizhi Shi, Xiuyun Tian, Kelong Fan, Chunyi Hao, and Xiyun Yan. Biomineralization synthesis of the cobalt nanozyme in sp94-ferritin nanocages for prognostic diagnosis of hepatocellular carcinoma. Acs Applied Materials & Interfaces. 2019, 11(10), 9747-9755. http://dx.doi.org/10.1021/acsami.8b20942
4. Jiuyang He, Kelong Fan, and Xiyun Yan. Ferritin drug carrier (FDC) for tumor targeting therapy. Journal of Controlled Release. 2019, 311, 288-300. http://dx.doi.org/10.1016/j.jconrel.2019.09.002
3. Lizeng Gao and Xiyun Yan. Nanozymes: biomedical applications of enzymatic Fe3O4 nanoparticles from in vitro to in vivo, in biological and bio-inspired nanomaterials: properties and assembly mechanisms. Adv Exp Med Biol. 2019, 291-312. http://dx.doi.org/10.1007/978-981-13-9791-29
2. Hui Ding, Yanjuan Cai, Lizeng Gao, Minmin Liang, Beiping Miao, Hanwei Wu, Yang Liu, Ni Xie, Aifa Tang, Kelong Fan, Xiyun Yan, and Guohui Nie. Exosome-like nanozyme vesicles for H2O2-responsive catalytic photoacoustic imaging of xenograft nasopharyngeal carcinoma. Nano Letters. 2019, 19(1), 203-209. http://dx.doi.org/10.1021/acs.nanolett.8b03709
1. Shen Xinyu, Wang Xingchen, Gu Caihong, Yan Feng, Pan Bo, Gao Lizeng, Yan Bingchun, Liu Qi, Hu Rong. A novel preparation of Panax japonicas with high bioequivalence of ginsenoside Rg3. Journal of Chinese Pharmaceutical Sciences. 2019, 28(9)，650-664. Accession Number: CSCD:6582624
