2006 - 2010 B.S., Dezhou University, Biophysics

2010 - 2011 Ph.D, University of Science and Technology of China

2011 - 2015 Ph.D, Institute of Biophysics (IBP), Chinese Academy of Sciences

2015 - 2019 Postdoctoral Fellow, Oregon Health & Science University

2020 - Principal Investigator, CAS Institute of Biophysics 　

Structure and Function of Membrane Protein.

1. Di Wu^#, Qihao Chen^#, Zhuoya Yu^#, Bo Huang^#, Jun Zhao^#, Yuhang Wang, Jiawei Su, Feng Zhou, Rui Yan, Na Li,Yan Zhao*, Daohua Jiang*. Transport and inhibition mechanisms of human VMAT2.Nature. 2024 Feb;626(7998):427-434.

2. Yanli Dong^#, Zhuoya Yu^#, Yue Li^#, Bo Huang, Qinru Bai, Yiwei Gao, Qihao Chen, Na Li, Lingli He,Yan Zhao*.EMBO J. 2024 Jan;43(1):14-31.

3. Yiwei Gao^#, Shuai Xu^#, Xiaoli Cui^#, Hao Xu, Yunlong Qiu, Yiqing Wei, Yanli Dong, Boling Zhu, Chao Peng, Shiqi Liu, Xuejun Cai Zhang, Jianyuan Sun, Zhuo Huang*,Yan Zhao*. Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca_V2.3.Nature Communications. 2023 Jan 31;14(1):516.

4. Yue Li^#, Tian Yuan^#, Bo Huang^#, Feng Zhou, Chao Peng, Xiaojing Li, Yunlong Qiu, Bei Yang,Yan Zhao*, Zhuo Huang*, Daohua Jiang*. Structure of human Na_V1.6 channel reveals Na⁺selectivity and pore blockade by 4,9-anhydro-tetrodotoxin.Nature Communications. 2023 Feb 23;14(1):1030.

5. Yuhang Wang^#, Chengcai Pan, Qihao Chen, Qing Xie , Yiwei Gao, Lingli He, Yue Li, Yanli Dong, Xingyu Jiang* &Yan Zhao*. Architecture and autoinhibitory mechanism of the plasma membrane Na⁺/H⁺antiporter SOS1 inArabidopsis.Nature Communications. 2023. Jul 26;14(1):4487.

6. Z. Zhang^#, H. Chen^#, Z. Geng^#, Z. Yu, H. Li, Y. Dong, H. Zhang, Z. Huang*, J. Jiang*,Y. Zhao*, Structural basis of ligand binding modes of human EAAT2,Nature Communications. 2022 Jun 9;13(1):3329.

7. Y. Dong^#, H. Li^#, A. Ilie^#, Y. Gao, A. Boucher, X. C. Zhang*, J. Orlowski*,Y. Zhao*, Structural basis of autoinhibition of the human NHE3-CHP1 complex,Science advances. 2022 May 27;8(21):eabn3925.

8. L. He^#, Z. Yu^#, Z. Geng^#, Z. Huang^#, C. Zhang, Y. Dong, Q. Chen, L. Sun, X. Ma, B. Huang, X. Wang,Y. Zhao, Structure, gating and pharmacology of human Ca_V3.3 channel.Nature Communications. 2022.Apr 19;13(1):2084.

9. X. Li^#, F. Xu^#, H. Xu^#, S. Zhang, Y. Gao, H. Zhang, Y. Dong, Y. Zheng, B. Yang, J. Sun, X. C. Zhang,Y. Zhao*, D. Jiang*. Structural basis for modulations of human Na_V1.3 by clinical drug and selective antagonist.Nature Communications. 2022 Mar 11;13(1):1286.

10. H. Zhang^#, J. Su^#, B. Li^#, Y. Gao, M. Liu, L. He, H. Xu, X. C. Zhang,Y. Zhao. Structure of human glycosylphosphatidylinositol transamidase.Nature Structural & Molecular Biology, 2022: 1-7

11. Yanli Dong^#, Yiwei Gao^#, Shuai Xu^#Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Bei Yang, Xuejun Cai Zhang, Daohua Jiang*, Zhuo Huang*,Y. Zhao*. Closed-state inactivation and pore-blocker modulation mechanisms of human Ca_V2.2.Cell Reports. 2021. 37, 109931.

12. Lingli He^#, Jiahui Sun^#, Yiwei Gao^#, Bin Li, Yuhang Wang, Yanli Dong, Weidong An, Hang Li, Bei Yang, Yuhan Ge, Xuejun Cai Zhang*, Yun Stone Shi* &Y. Zhao*. Kainate receptor modulation by NETO2.Nature. 2021 Nov;599(7884):325-329.

13. Yanli Dong^#, Yiwei Gao^#, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang*, John Orlowski* &Y. Zhao*. Structure and mechanism of the human NHE1-CHP1 complex.Nature Communications. 2021. 9;12(1):3474.

14. Rong Y, Jiang J.H, Gao Y.W, Guo J.L, Song D.F, Liu W.H, Zhang M.M,Zhao Y*, Xiao B.L*, Liu Z.F*. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells.Elife, 2021.10, e71474.

15.Y. Zhao, S. Chen, A. C. Swensen, W. J. Qian, E. Gouaux, Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.Science, 2019. 364, 355-362.

16. Y. Xin,Y. Zhao, J. Zheng, H. Zhou, X. C. Zhang, C. Tian, & Y. Huang. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion.The FASEB Journal, 2018. 32(5), 2411-2421.

17. S. Chen^#,Y. Zhao^#, Y. Wang, M. Shekhar, E. Tajkhorshid and E. Gouaux. Activation and desensitization mechanism of AMPA receptor - TARP complex by cryo-EM.Cell, 2017.170, 1234-1246.

18.Y. Zhao^#, S. Chen^#, C. Yoshioka, I. Baconguis, E. Gouaux. Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.Nature, 2016.536(7614): 108-111.　　

19. G. Mao^#,Y. Zhao^#, X. Kang, Z. Li, Y. Zhang, X. Wang, F. Sun, K. Sankaran and XC. Zhang. Crystal structure ofE. colilipoprotein diacylglyceryl transferase.Nature communications, 2016.7: 10198.　　

20. J. Heng,Y. Zhao, M. Liu, Y. Liu, J. Fan, X. Wang,Y. Zhao, and XC. Zhang. Substrate-bound structure of theE. colimultidrug resistance transporter MdfA.Cell research, 2015.25(9): 1060. 　　

21. X.C. Zhang,Y. Zhao, J. Heng, D. Jiang. Energy coupling mechanisms of MFS transporters.Protein Science, 2015.24(10): 1560-1579.　

22.Y. Zhao^#, G. Mao^#, M. Liu, L. Zhang, X. Wang, X.C. Zhang. Crystal structure of theE. colipeptide transporter YbgH.Structure, 2014.22(8): 1152-1160.　　

23. B. Cao^#,Y. Zhao^#, Y. Kou, D. Ni, X.C. Zhang and Y. Huang. Structure of the nonameric bacterial amyloid secretion channel.Proceedings of the National Academy of Sciences, 2014.111(50): E5439-E5444.　　　

24. D. Jiang^#,Y. Zhao^#, J. Fan, X. Liu, Y. Wu, W. Feng, X.C. Zhang. Atomic resolution structure of theE. coliYajR transporter YAM domain.Biochemical and biophysical research communications, 2014.450(2): 929-935.　　

25. S. Qiao, Q. Luo,Y. Zhao, X.C. Zhang, Y. Huang. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane.Nature, 2014.511(7507): 108.

26. J. Fan, D. Jiang,Y. Zhao, J. Liu, and X.C. Zhang. Crystal structure of lipid phosphataseEscherichia coliphosphatidylglycerophosphate phosphatase B.Proceedings of the National Academy of Sciences, 2014.111(21): 7636-7640. 　　

27. D. Jiang^#,Y. Zhao^#, X. Wang^#, J. Fan, J. Heng, X. Liu, W. Feng, X. Kang, B. Huang, J. Liu and X.C. Zhang. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A.Proceedings of the National Academy of Sciences, 2014.110(36): 14664-14669.　　

28. W. Zhang, F. Zeng, Y. Liu,Y. Zhao, H. Lv, L. Niu, M. Teng and X. Li (2013). Crystal Structures and RNA-Binding Properties of the RRMs of hnRNP-L: Insights into Its Roles in Alternative-splicing Regulation.Journal of Biological Chemistry, 2014 288(31), 22636-22649.　　

(From Yan Zhao, March 18, 2024)