
Science Bulletin, 16 June, 2025, DOI:https://doi.org/10.1016/j.scib.2025.06.012
An unconventional topology of betacoronavirus membrane protein drives viral assembly
Rui Lyu, Kaili Li, Lingjiao Xiang, Yingjian Li, Yaotian Liang, Xue Tan, Xiaoya Huang, Yu Chen, Hongyu Deng, Junjie Hu
Abstract
SARS-CoV-2 expresses four structural proteins, the membrane (M), envelope (E), spike (S), and nucleocapsid (N) proteins, along with a replicated viral genome, and delineates the process of viral assembly. S, E, and M are integral membrane proteins that are synthesized in the endoplasmic reticulum (ER), and N is cytosolic and escorts the viral genome for assembly. Based on findings for other betacoronaviruses, S/E/M have been proposed to meet in the ER-Golgi intermediate compartment (ERGIC), joined by N-genome, even though some assembled SARS-CoV-2 virions have been seen in the Golgi apparatus. The mechanism of SARS-CoV-2 assembly remains elusive.
文章链接:https://www.sciencedirect.com/science/article/pii/S2095927325006206?via%3Dihub
相关报道://m.wyreworks.com/jz/zxdt/202506/t20250627_7876109.html
附件下载: